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Pharmaceutical Chemistry

Department of Pharmaceutical Chemistry is an integral part of pharmacy education involving several aspects of new drug discovery and development in collaboration with other disciplines of pharmacy. As a part of undergraduate teaching and learning, various subjects included are Pharmaceutical Inorganic Chemistry, Biochemistry, Pharmaceutical Organic Chemistry, Medicinal Chemistry, and Computer Aided Drug Design. The department is extensively involved in the postgraduate programme in ‘Pharmaceutical Chemistry” which involves learning of various aspects of Advanced Organic Chemistry including Process Chemistry, Advanced Medicinal Chemistry and CADD. The separate subject for practical provides extensive and diversified experience to students to perform different experiments from all required areas. Extensive use of modern audio-visual teaching aids and molecular models make the lessons interesting and student-centric. The department has collaborations with various research organizations, industries and basic science departments where students can participate in interdisciplinary research projects relevant to core areas. The research projects help students to get deep insights in the research area and help to develop expertise. The students are also encouraged for various other activities like personality, communication and soft skills development; scientific writing; workshops for improvement in presentation and documentation skills, etc. Alumni students of the department are placed at various places like R&D, CRO and academic institutions, etc. Many past students are also pursuing their doctoral studies in reputed universities across the globe.

Department of Pharmaceutical Chemistry is constituted by four spacious laboratories; two as postgraduate and two as undergraduate laboratories. The laboratories are designed and equipped with several unique features and facilities including central ventilation system and very sophisticated fume hoods attached to nitrogen, vacuum and water supply. Emergency shower rooms are provided in each laboratory with a special focus on the safety of the workforce. The laboratories are spacious and ventilated, having adequate space for students to carry out experimental work smoothly.

Research laboratories are equipped with various basic and essential instruments useful for the synthesis of NCEs. This includes Precision Digital Balance, Multimagnetic Stirrer, Rotamantle, Constant Temperature Water-bath, Digital Mechanical Stirrers, High-Speed Centrifuge, and Hot Air Oven. Department activities also involved many advanced instruments to facilitate the research work, which includes Microwave Synthesizer, FT-IR with Microscope, MPLC, Gel Electrophoresis, Rotary Vacuum Evaporator, Precision Digital Melting Point Apparatus, Cryogenic Bath, Digital Polarimeter and GOLD Suit Software.

Department of Pharmaceutical Chemistry has students registered for Doctoral studies as well as Masters in Pharmaceutical Chemistry. The faculty too is engaged in research for their Doctoral degrees. In the future, the department is planning to extend its wings extensively in the areas of computational chemistry, microwave-assisted organic synthesis & solid phase synthesis by registering several doctorates and postgraduate students from various parts of the country.

The department also focuses on the development of novel NCEs targeting various diseases. Effectiveness of designing compound depends upon how precisely, it binds with important amino acids of the target receptor and orient itself in the binding pocket, so to inhibit target protein. Study of the binding pocket of the target receptor gives great insight which is followed by conventional ligand based and structure-based computational approaches. Overall in the design process of the novel compounds; pharmacophore-based virtual screening, 3D-QSAR studies, and molecular dynamics assisted molecular docking study is carried out before actual synthesis.

Several students have registered for PhD degree in the Department of Pharmaceutical Chemistry and received fellowship from INSPIRE-DST, ICMR, CSIR and Nirma University. Students of the department have also received the international fellowship. The department has received Research Projects for more than four million from various agencies like DST, Govt. of India, GUJCOST and from Nirma University. The department has published several research papers in International Journals like European Journal of Medicinal Chemistry, PLOS, RSC Advances, Bioorganic and Medicinal Chemistry Letters, MedChemComm, Behavioural Brain Research, Structural Chemistry, Medicinal Chemistry Research; as well as several review papers in journals like Medicinal Research Reviews, European Journal of Medicinal Chemistry, Mini Reviews in Medicinal Chemistry, Current Medicinal Chemistry, etc. Faculty members of the department also published three patents in Indian patent. The department regularly organizes several National seminars like Recent Advances in Drug Discovery, Hands-on Training in Drug Discovery Software, Workshop on Interpretation of Spectral Data, etc.

  • Drug design of NCEs using various in silico methods
  • Convention and solid / liquid phase combinatorial synthesis, including microwave assisted synthesis of potentially useful, novel chemical entities for various disorders
  • Various approaches for solubility enhancement

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